Does succinate dehydrogenase inhibition with malonate at the onset of reperfusion reduce infarct size in isolated mice hearts?
Malonate administration at reperfusion reduces infarct size in isolated mice hearts by inhibiting succinate dehydrogenase and preventing mitochondrial permeability transition.
Succinate dehydrogenase inhibition with malonate at the onset of reperfusion reduces infarct size in isolated mice hearts through reduction in ROS production and mitochondrial permeability transition pore opening.
Valls-Lacalle et al. (Wed,) studied this question.