Why the study?
Does extended duration of surgical antimicrobial prophylaxis increase adverse events without reducing surgical site infections?
Does extended duration of surgical antimicrobial prophylaxis increase adverse events without reducing surgical site infections?
Limiting the duration of surgical antimicrobial prophylaxis can reduce adverse events such as AKI and C. difficile infection without increasing the risk of surgical site infections.
This is the authors' abstract. We don't add key points for this paper.
Increasing duration of antimicrobial prophylaxis was associated with higher odds of AKI and C difficile infection in a duration-dependent fashion; extended duration did not lead to additional SSI reduction. These findings highlight the notion that every day matters and suggest that stewardship efforts to limit duration of prophylaxis have the potential to reduce adverse events without increasing SSI.
Supports limiting prophylaxis duration to curb AKI and C. difficile; leaves open randomized confirmation of no SSI benefit.
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Branch‐Elliman et al. (2019) studied this question.
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