Resting Heart Rate is an Independent Predictor of Death in Patients with Colorectal, Pancreatic, and Non-Small Cell Lung Cancer: Results of a Prospective Cardiovascular Long-Term Study

Markus S. Anker; Nicole Ebner; Bert Hildebrandt; Jochen Springer; Marianne Sinn; Hanno Riess; Stefan D. Anker; Ulf Landmesser; Wilhelm Haverkamp; Stephan von Haehling

doi:10.1002/ejhf.670

December 1, 2016European Journal of Heart Failure

Resting Heart Rate is an Independent Predictor of Death in Patients with Colorectal, Pancreatic, and Non-Small Cell Lung Cancer: Results of a Prospective Cardiovascular Long-Term Study

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Why the study?

Does resting heart rate predict survival in patients with advanced colorectal, pancreatic, and non-small cell lung cancer?

Key Points

To determine whether resting heart rate predicts survival independently of tumour stage and haemoglobin levels in patients with advanced colorectal, pancreatic, and non-small cell lung cancer.
Prospective long-term cardiovascular cohort study evaluating individuals diagnosed with advanced colorectal, pancreatic, and non-small cell lung cancer.
Assessed resting heart rate alongside standard clinical covariates, specifically haemoglobin concentrations and tumour stage.
Resting heart rate significantly and independently predicted survival across colorectal, pancreatic, and non-small cell lung cancer populations.
The association with mortality persisted after adjustment for haemoglobin levels and baseline tumour stage, highlighting resting heart rate as a potential therapeutic target.

Structured PICO

Does resting heart rate predict survival in patients with advanced colorectal, pancreatic, and non-small cell lung cancer?

P

Population

Patients with advanced colorectal, pancreatic, and non-small cell lung cancer

I

Intervention

Resting heart rate (as an exposure/predictor)

O

Outcome

Death / survivalhard clinical

Resting heart rate is an independent predictor of mortality in advanced cancer patients and may represent a novel therapeutic target.

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Implication

Resting heart rate may aid prognostication in advanced cancers; leaves open whether modulation improves survival.

Abstract

The present study is the first to show that resting heart rate independently of haemoglobin and tumour stage predicts survival in patients with advanced colorectal, pancreatic, and non-small cell lung cancer, and may therefore represent a therapeutic target.

Discussion

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Cite This Study

Anker et al. (2016) studied this question.

synapsesocial.com/papers/69dd66ae629747396240cf01 https://doi.org/10.1002/ejhf.670

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Resting Heart Rate is an Independent Predictor of Death in Patients with Colorectal, Pancreatic, and Non-Small Cell Lung Cancer: Results of a Prospective Cardiovascular Long-Term Study

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Resting Heart Rate is an Independent Predictor of Death in Patients with Colorectal, Pancreatic, and Non-Small Cell Lung Cancer: Results of a Prospective Cardiovascular Long-Term Study

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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