Why the study?
Does resting heart rate predict all-cause, cardiovascular and cancer mortality in adults aged 40-80 years?
Does resting heart rate predict all-cause, cardiovascular and cancer mortality in adults aged 40-80 years?
Resting heart rate is a significant predictor of all-cause and cardiovascular mortality, independent of major cardiovascular risk factors.
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Resting heart rate may refine mortality risk stratification in adults 40-80; leaves open causal inference and need for interventional trials.
AIMS: The association between resting heart rate and changes in heart rate with all-cause, cardiovascular and cancer mortality was studied among 1827 men and 2929 women, aged 40-80 years, followed for 12 years. METHODS AND RESULTS: After adjustment for initial age, serum cholesterol, body mass index, systolic blood pressure, smoking and diabetes, the all-cause mortality hazard ratio was 1.7 (95% confidence interval 1.4-2.2) for heart rate increments of 20 beats.min-1 for men and 1.4 (confidence interval 1.1-1.8) for women. For cardiovascular mortality, the risk estimates were 1.7 (confidence interval 1.2-2.6) for men and 1.3 (confidence interval 0.9-2.0) for women. We observed no significant association between heart rate and cancer mortality. For women, stronger predictive information for all-cause mortality was provided if changes in heart rate were evident at the 2-year review. CONCLUSION: The resting heart rate is a predictor of mortality, independent of major cardiovascular risk factors.
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Mensink et al. (1997) studied this question.
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