What question did this study set out to answer?

To quantify the excess incidence of ductal carcinoma in situ and invasive breast cancer during screening and subsequent deficits post-screening to estimate overdiagnosis rates.

January 25, 2013International Journal of CancerOpen Access

Overdiagnosis among women attending a population‐based mammography screening program

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Authors

RFRagnhild Sørum FalkOslo University Hospital SHSolveig HofvindNorwegian Institute of Public Health PSPer SkaaneOslo University Hospital

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Implication

Cohort study reveals a 10% to 20% overdiagnosis rate in screened women, highlighting the balance of screening benefits and excess detection.

Key Points

To quantify the excess incidence of ductal carcinoma in situ and invasive breast cancer during screening and subsequent deficits post-screening to estimate overdiagnosis rates.
Analyzed 702,131 women invited to the Norwegian Breast Cancer Screening Program between 1995 and 2009.
Calculated incidence rate ratios (IRRs) comparing attendees to non-attendees, adjusted using the Mantel-Haenszel (MH) method.
Applied adjusted IRRs to reference rates to model lifetime overdiagnosis among women aged 50 years and older.
Screening attendance increased cancer detection during active screening years: MH IRR was 1.86 (95% CI 1.65–2.09) for women aged 50–51 and 1.56 (95% CI 1.45–1.68) for women aged 52–69.
A 30% deficit in cancer incidence emerged 1–10 years post-screening among women aged 70–79 (MH IRR 0.70, 95% CI 0.62–0.80).
Total estimated overdiagnosis ranged from 10% to 20%, depending on whether analyses assessed all invited or strictly screened women and the specific cancer outcome.

Cite This Study

Falk et al. (2013) studied this question.

synapsesocial.com/papers/69de59ec210a0977fce93e0d https://doi.org/10.1002/ijc.28052

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Implication

Cohort study reveals a 10% to 20% overdiagnosis rate in screened women, highlighting the balance of screening benefits and excess detection.

Overdiagnosis among women attending a population‐based mammography screening program

Discussion

Member takes

Implication

Key Points

Cite This Study

Overdiagnosis among women attending a population‐based mammography screening program

Discussion

Member takes

Implication

Key Points

Cite This Study

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