Why the study?
Does Roux-en-Y gastric bypass alter the disposition of fenofibrate and posaconazole?
Does Roux-en-Y gastric bypass alter the disposition of fenofibrate and posaconazole?
RYGB significantly decreases the oral disposition of posaconazole but does not alter fenofibrate disposition, which may require dose adjustments for posaconazole post-surgery.
May warrant posaconazole dose adjustment post-RYGB; leaves open confirmation in larger pharmacokinetic studies.
The disposition of fenofibrate was not altered after RYGB, whereas the oral disposition of posaconazole was significantly decreased following RYGB.
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Gesquiere et al. (2016) studied this question.
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