Does Pulsed Field Ablation safely and effectively isolate the pulmonary vein and SVC while sparing nerves and venous tissue in a porcine model?
PFA-based pulmonary vein and SVC isolation is safe and efficacious in a porcine model, sparing nerves and venous tissue, which supports first-in-human trials.
In this chronic porcine study, PFA-based pulmonary vein and SVC isolation were safe and efficacious with demonstrable sparing of nerves and venous tissue. This preclinical study provided the scientific basis for the first-in-human endocardial PFA studies.
Koruth et al. (Sun,) studied this question.