Key result
Epicardial irreversible electroporation ablation in a porcine model caused no clinically relevant coronary artery damage or stenosis at 3 weeks, even when applied directly on the LAD.
Why the study?
Does irreversible electroporation (IRE) ablation cause coronary artery damage in a porcine model?
Does irreversible electroporation (IRE) ablation cause coronary artery damage in a porcine model?
Irreversible electroporation (IRE) ablation does not cause clinically relevant coronary artery damage in a porcine model, suggesting it can be safely applied near coronary arteries.
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Supports preclinical safety of epicardial IRE near coronaries; leaves open human translation pending clinical trials.
Pré et al. (2012) studied Preclinical porcine model (n=11). Irreversible electroporation (IRE) ablation vs. Untreated hearts was evaluated on Coronary damage (intimal hyperplasia). Epicardial irreversible electroporation ablation in a porcine model caused no clinically relevant coronary artery damage or stenosis at 3 weeks, even when applied directly on the LAD.
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