Population
Cardiac fibroblasts and cardiac myocytes in a cell culture model
Comparison
Atrial natriuretic peptide treatment or… vs Untreated fibroblasts or ET-1 treatment alone
Design
Preclinical
Authors
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ANP's antifibrotic effects in fibroblast culture are hypothesis-generating; leaves open translation to in vivo cardiac remodeling or therapy.
ANP acts as a paracrine inhibitor of cardiac fibroblast proliferation by suppressing ET-1 expression via a GATA4-dependent mechanism, highlighting its antifibrotic properties.
Glenn et al. (2009) studied this question.
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