Why the study?
Is circulating NRG-1β associated with disease severity and adverse outcomes in patients with chronic heart failure?
Is circulating NRG-1β associated with disease severity and adverse outcomes in patients with chronic heart failure?
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Serum NRG-1β is identified as a novel biomarker associated with disease severity and adverse outcomes in chronic heart failure.
Circulating NRG-1beta is independently associated with heart failure severity and risk of death or cardiac transplantation. These findings support a role for NRG-1/ErbB signaling in human heart failure and identify serum NRG-1beta as a novel biomarker that may have clinical applications.
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Ky et al. (2009) studied this question.
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