scAAV-mediated intra-articular gene transfer of IL-1Ra is efficient in both normal and inflamed joints, demonstrating potential for joint-directed gene therapy.
May inform intra-articular gene therapy development for arthritis; hypothesis-generating in animal models and requires human trials.
scAAV-mediated intra-articular gene transfer is robust and similarly efficient in both normal and inflamed joints; the resulting transgenic expression is sufficient to achieve biological relevance in joints of human proportion.
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Kay et al. (2009) studied this question.
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