Loss of single fiber myosin protein content is a potential molecular mechanism underlying muscle weakness and exercise limitation in patients with heart failure.
Myosin loss may underlie skeletal muscle weakness in HF; hypothesis-generating for myosin-targeted therapies to improve exercise capacity.
Collectively, our results show that HF alters the quantity and functionality of the myosin molecule in skeletal muscle, leading to reduced tension in myosin heavy chain I fibers. Loss of single fiber myosin protein content represents a potential molecular mechanism underlying muscle weakness and exercise limitation in patients with HF.
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Miller et al. (2009) studied this question.
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