Why the study?
Does congestive heart failure induce diaphragm weakness at the single-fiber level by decreasing myosin content and altering cross-bridge kinetics in a rat model?
Does congestive heart failure induce diaphragm weakness at the single-fiber level by decreasing myosin content and altering cross-bridge kinetics in a rat model?
In a rat model of CHF, diaphragm weakness at the single-fiber level is driven by a loss of myosin content associated with increased caspase-3 and proteasome activity, as well as decreased Ca2+ sensitivity and slower cross-bridge kinetics.
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May impair ventilation in CHF; leaves open human relevance and myosin-targeted therapies.
Hees et al. (2007) studied this question.
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