Treosulfan-based conditioning strategies in older or frail patients undergoing allogeneic hematopoietic cell transplantation

This is the authors' abstract. We don't add key points for this paper.

Treosulfan is a safe and effective agent for conditioning in older or comorbid allo-HCT recipients, exhibiting comparable or superior survival outcomes compared to reduced intensity regimens and busulfan, with similar or lower rates of graft-versus-host disease and reduced non-relapse mortality. Before allo-HCT, geriatric assessment and evaluation of the underlying comorbidities are important for the selection of a personalized conditioning regimen.