November 13, 2021New England Journal of Medicine248 citationsOpen Access
View Full PaperConcomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation
Structured PICO
Does concomitant tricuspid repair reduce primary-end-point events in patients with degenerative mitral regurgitation undergoing mitral-valve surgery?
P
Population
Patients with degenerative mitral regurgitation undergoing mitral-valve surgery
I
Intervention
Concomitant tricuspid repair (TA)
C
Comparator
Mitral-valve surgery alone
O
Outcome
Primary-end-point event at 2 yearscomposite
Concomitant tricuspid repair during mitral-valve surgery reduces progression to severe tricuspid regurgitation at 2 years but increases the risk of permanent pacemaker implantation.
Abstract
Among patients undergoing mitral-valve surgery, those who also received TA had a lower incidence of a primary-end-point event than those who underwent mitral-valve surgery alone at 2 years, a reduction that was driven by less frequent progression to severe tricuspid regurgitation. Tricuspid repair resulted in more frequent permanent pacemaker implantation. Whether reduced progression of tricuspid regurgitation results in long-term clinical benefit can be determined only with longer follow-up. (Funded by the National Heart, Lung, and Blood Institute and the German Center for Cardiovascular Research; ClinicalTrials.gov number, NCT02675244.).