Why the study?
Does an amlodipine-based regimen improve retinal microvascular measurements compared to an atenolol-based regimen in patients on antihypertensive therapy?
Population
720 patients in a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial on stable antihypertensive…
Comparison
Amlodipine-based antihypertensive regimen vs Atenolol-based antihypertensive regimen
Design
RCT
Authors
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Supports amlodipine over atenolol for retinal microvascular remodeling in hypertension; extends RCT evidence on antihypertensive class effects.
Does an amlodipine-based regimen improve retinal microvascular measurements compared to an atenolol-based regimen in patients on antihypertensive therapy?
An amlodipine-based antihypertensive regimen is associated with beneficial microvascular structural responses, specifically a smaller retinal arteriolar length-to-diameter ratio, compared to an atenolol-based regimen.
Thom et al. (2009) studied this question.
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