Why the study?
Does amlodipine-based therapy compared to atenolol-based therapy improve central aortic pressures in patients requiring blood pressure-lowering treatment?
Does amlodipine-based therapy compared to atenolol-based therapy improve central aortic pressures in patients requiring blood pressure-lowering treatment?
Amlodipine-based therapy lowers central aortic pressures more effectively than atenolol-based therapy despite similar brachial blood pressure reductions, which may explain differences in clinical outcomes.
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Amlodipine-based regimens should be preferred over atenolol for central aortic BP lowering; extends evidence that brachial BP underestimates regimen-specific hemodynamic effects.
Williams et al. (2006) studied this question.
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