Why the study?
Does amlodipine-based therapy reduce central blood pressure and wave reflection compared to atenolol-based therapy in patients from the ASCOT trial?
Does amlodipine-based therapy reduce central blood pressure and wave reflection compared to atenolol-based therapy in patients from the ASCOT trial?
Amlodipine-based therapy lowers central systolic blood pressure more effectively than atenolol-based therapy due to reduced wave reflection, which may explain differences in cardiovascular outcomes and left ventricular mass.
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Amlodipine-based therapy may be preferred for central pressure reduction beyond brachial readings; extends ASCOT by linking wave reflection to outcome differences.
Manisty et al. (2009) studied this question.
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