Why the study?
Does carvedilol improve central augmentation index and pulse pressure amplification compared to atenolol in patients with essential hypertension?
Population
41 patients with essential hypertension and without significant concomitant cardiovascular disease
Comparison
Controlled-release carvedilol, force-titrated to… vs Atenolol, force-titrated to 100 mg once daily…
Design
RCT, Randomly assigned
Follow-up
4 weeks
Authors
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Carvedilol may be preferred over atenolol for central hemodynamics in hypertension; extends evidence favoring vasodilating beta-blockers in trials and practice.
Does carvedilol improve central augmentation index and pulse pressure amplification compared to atenolol in patients with essential hypertension?
Carvedilol provides more favorable effects on arterial compliance and wave reflection compared to atenolol in patients with essential hypertension.
Shah et al. (2011) studied this question.
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