Why the study?
Does enalapril compared to hydrochlorothiazide improve retinal vascular changes in previously untreated men with mild to moderate essential hypertension?
Population
28 previously untreated men with mild to moderate essential hypertension
Comparison
Enalapril for 26 weeks vs Hydrochlorothiazide for 26 weeks
Design
RCT, Double-blind; photos examined by the same observer without knowledge of…
Follow-up
26 weeks
Authors
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Enalapril may be preferred for retinal vascular protection in mild hypertension; extends evidence of class-specific microvascular effects.
Does enalapril compared to hydrochlorothiazide improve retinal vascular changes in previously untreated men with mild to moderate essential hypertension?
Enalapril, but not hydrochlorothiazide, positively affects hypertensive retinopathy, which correlates with structural cardiovascular changes such as left ventricular hypertrophy.
Dahlöf et al. (1992) studied this question.
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