December 1, 2000Journal of Biological ChemistryOpen Access

PACT, a Stress-modulated Cellular Activator of Interferon-induced Double-stranded RNA-activated Protein Kinase, PKR

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Why the study?

Does PACT activate PKR in response to stress signals in mammalian cells?

Population

Mammalian cells

Comparison

Exposure to stress signals and overexpression of… vs Unstressed cells or cells without PACT…

Design

Preclinical

Authors

CPChandrashekhar V. PatelUniversity of North Carolina at Chapel Hill IHIndhira HandyUniversity of South Carolina TGTiffany GoldsmithUniversity of South Carolina

Discussion

Member takes

Implication

Hypothesis-generating for PACT-PKR stress signaling; leaves open relevance to cardiovascular apoptosis in vivo.

Structured PICO

Does PACT activate PKR in response to stress signals in mammalian cells?

Population

Mammalian cells

Intervention

Exposure to stress signals (serum starvation, peroxide, or arsenite treatment) and overexpression of PACT

Comparator

Unstressed cells or cells without PACT overexpression

Outcome

Activation of PKR and phosphorylation of eIF2alphasurrogate

Identifies PACT as a novel stress-modulated physiological activator of PKR, linking cellular stress to apoptosis via eIF2alpha phosphorylation.

Cite This Study

Patel et al. (2000) studied this question.

synapsesocial.com/papers/69deace7499d77a496b0c7e7 https://doi.org/10.1074/jbc.m004762200

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PACT, a Stress-modulated Cellular Activator of Interferon-induced Double-stranded RNA-activated Protein Kinase, PKR

Discussion

Member takes

Implication

Structured PICO

Cite This Study

PACT, a Stress-modulated Cellular Activator of Interferon-induced Double-stranded RNA-activated Protein Kinase, PKR

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider