Why the study?
Does cerebrovascular reactivity (measured by breath-holding index) predict cognitive decline in patients with Alzheimer disease?
Does cerebrovascular reactivity (measured by breath-holding index) predict cognitive decline in patients with Alzheimer disease?
Impaired cerebrovascular reactivity, measured by breath-holding index, is a significant predictor of cognitive decline over 12 months in patients with Alzheimer's disease.
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BHI may identify AD patients at risk of decline; hypothesis-generating and should not yet change practice.
Silvestrini et al. (2006) studied this question.
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