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November 10, 2001BMJOpen Access

Analysing controlled trials with baseline and follow up measurements

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Authors

AVAndrew J. VickersDADouglas G. Altman

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Overview

Randomized trial analyzes treatment effects on pain in chronic conditions, indicating measurement methods impact results.

Key Points

  • This research aims to analyze the statistical methods used for assessing treatment effects in randomized trials with baseline and follow-up measurements.
  • Conducted a randomized trial focusing on chronic conditions.
  • Measured continuous variables at baseline and follow-up.
  • Compared follow-up scores and calculated change scores.
  • Mean pain scores were 15 mm lower (95% CI 10 to 20 mm) in the treatment group at follow-up.
  • Pain reductions were 20 mm greater (95% CI 16 to 24 mm) on treatment than control when using change scores.
  • The effectiveness of treatment varied based on the correlation between baseline and follow-up scores.

Cite This Study

Vickers et al. (2001) studied this question.

synapsesocial.com/papers/69dff511ca6b6a2615860476https://doi.org/10.1136/bmj.323.7321.1123
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