What question did this study set out to answer?

Develop a noninvasive deep-brain neuromodulation strategy using near-infrared light and hybrid optoelectronic nanoparticles that bypasses the need for genetic modification.

June 13, 2025Science AdvancesOpen Access

Instant noninvasive near-infrared deep brain stimulation using optoelectronic nanoparticles without genetic modification

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Authors

SJShuang JinChinese Academy of Sciences JLJiazhi LiChinese Academy of Sciences LJLuyue JiangChinese Academy of Sciences

Discussion

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Implication

Preclinical study demonstrates deep brain stimulation via near-infrared optoelectronic nanoparticles in mice, suggesting a non-genetic route for neuromodulation.

Key Points

Develop a noninvasive deep-brain neuromodulation strategy using near-infrared light and hybrid optoelectronic nanoparticles that bypasses the need for genetic modification.
Engineered hybrid upconversion and photovoltaic (HUP) nanoparticles to convert deeply penetrating near-infrared (NIR) light into localized electrical stimuli.
Performed in vitro patch-clamp electrophysiology to evaluate immediate neuronal activation upon HUP application and light exposure.
Tested in vivo transcranial NIR neuromodulation in wild-type mice targeting the medial septum and ventral tegmental area 7 days post-injection.
Patch-clamp recordings confirmed direct neuronal activation upon NIR illumination mediated by HUP nanoparticles.
In vivo transcranial NIR stimulation reliably modulated regional neuronal activity, successfully suppressed seizures, and triggered dopamine release without genetic alteration.

Cite This Study

Jin et al. (2025) studied this question.

synapsesocial.com/papers/69deb8337702a00918b0c937 https://doi.org/10.1126/sciadv.adt4771

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June 13, 2025Science AdvancesOpen Access

Instant noninvasive near-infrared deep brain stimulation using optoelectronic nanoparticles without genetic modification

View Full Paper

Ask AI

Bookmark

Authors

SJShuang JinChinese Academy of Sciences JLJiazhi LiChinese Academy of Sciences LJLuyue JiangChinese Academy of Sciences

Discussion

Member takes

Implication

Preclinical study demonstrates deep brain stimulation via near-infrared optoelectronic nanoparticles in mice, suggesting a non-genetic route for neuromodulation.

Key Points

Develop a noninvasive deep-brain neuromodulation strategy using near-infrared light and hybrid optoelectronic nanoparticles that bypasses the need for genetic modification.
Engineered hybrid upconversion and photovoltaic (HUP) nanoparticles to convert deeply penetrating near-infrared (NIR) light into localized electrical stimuli.
Performed in vitro patch-clamp electrophysiology to evaluate immediate neuronal activation upon HUP application and light exposure.
Tested in vivo transcranial NIR neuromodulation in wild-type mice targeting the medial septum and ventral tegmental area 7 days post-injection.
Patch-clamp recordings confirmed direct neuronal activation upon NIR illumination mediated by HUP nanoparticles.
In vivo transcranial NIR stimulation reliably modulated regional neuronal activity, successfully suppressed seizures, and triggered dopamine release without genetic alteration.

Cite This Study

Jin et al. (2025) studied this question.

synapsesocial.com/papers/69deb8337702a00918b0c937 https://doi.org/10.1126/sciadv.adt4771

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