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November 19, 2025Advanced ScienceOpen Access

A Closed‐Loop‐Capable Neural Interface Platform for Deep Brain Modulation via Integrated Non‐Viral Gene Delivery, NIR Optogenetics, and Electrophysiological Recording

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Authors

CCChao‐Yi ChuZCZih-Huei ChenCLChun-Wei Liang

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Overview

This platform enhances deep-brain optogenetic engineering with precise neuromodulation using near-infrared light and gene delivery.

Key Points

  • The study aims to develop a closed-loop neural interface for precise control of neural circuits.
  • Integration of non-viral gene delivery and optogenetic stimulation into a single device.
  • Use of 3D gold inverse opal microelectrode for gene transfection and neural signal acquisition.
  • Implementation of localized surface plasmon resonance for light activation.
  • Successful opsin expression and light-evoked neural activity observed in vivo.
  • Demonstrated fiber-free operation and stable performance in the hippocampal dentate gyrus.

Cite This Study

Chu et al. (2025) studied this question.

synapsesocial.com/papers/6924fed1c0ce034ddc350ec3https://doi.org/10.1002/advs.202515060
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