What question did this study set out to answer?

Develop and evaluate a fully implantable, closed-loop opto-electrical neural interface designed for freely moving rodents to aid motor neuron disease research.

August 26, 2022IEEE Transactions on Biomedical Circuits and SystemsOpen Access

A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies

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Authors

FLFangqi Liu YWYu Wu NANoora Almarri

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Overview

Preclinical bioengineering study demonstrates a wireless closed-loop neural interface in freely moving rodents, suggesting new avenues for motor neuron disease therapy.

Key Points

Develop and evaluate a fully implantable, closed-loop opto-electrical neural interface designed for freely moving rodents to aid motor neuron disease research.
Designed a 0.18 μm CMOS integrated circuit featuring four stimulators with 16 optical and electrical channels (1.5 Hz to 50 kHz arbitrary waveforms) and a programmable neural recording front-end.
Integrated a Qi wireless inductive power transfer link with a rechargeable backup battery, packaged within a 40 mm × 20 mm × 10 mm encapsulated module.
Implemented a bidirectional Bluetooth Low Energy telemetry link controlled via a graphical user interface to modulate stimulation parameters in freely moving animals.
The wireless inductive link delivered over 100 mW of power across distances up to 2 cm.
The integrated backup battery sustained continuous 10 mA stimulation currents for 2.5 hours without inductive power.
Bench measurements verified electrical operational performance across stimulation frequencies and validated the reliability of the device packaging.

Cite This Study

Liu et al. (2022) studied this question.

synapsesocial.com/papers/6a95d5add6dd5cd218250555 https://doi.org/10.1109/tbcas.2022.3202026

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August 26, 2022IEEE Transactions on Biomedical Circuits and SystemsOpen Access

A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies

View Full Paper

Ask AI

Bookmark

Authors

FLFangqi Liu YWYu Wu NANoora Almarri

Discussion

Member takes

Overview

Preclinical bioengineering study demonstrates a wireless closed-loop neural interface in freely moving rodents, suggesting new avenues for motor neuron disease therapy.

Key Points

Develop and evaluate a fully implantable, closed-loop opto-electrical neural interface designed for freely moving rodents to aid motor neuron disease research.
Designed a 0.18 μm CMOS integrated circuit featuring four stimulators with 16 optical and electrical channels (1.5 Hz to 50 kHz arbitrary waveforms) and a programmable neural recording front-end.
Integrated a Qi wireless inductive power transfer link with a rechargeable backup battery, packaged within a 40 mm × 20 mm × 10 mm encapsulated module.
Implemented a bidirectional Bluetooth Low Energy telemetry link controlled via a graphical user interface to modulate stimulation parameters in freely moving animals.
The wireless inductive link delivered over 100 mW of power across distances up to 2 cm.
The integrated backup battery sustained continuous 10 mA stimulation currents for 2.5 hours without inductive power.
Bench measurements verified electrical operational performance across stimulation frequencies and validated the reliability of the device packaging.

Cite This Study

Liu et al. (2022) studied this question.

synapsesocial.com/papers/6a95d5add6dd5cd218250555 https://doi.org/10.1109/tbcas.2022.3202026

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