Activin A may play a role in the pathogenesis of heart failure by inducing gene expression related to myocardial remodeling.
Together with our demonstration of activin A-induced gene expression in neonatal cardiomyocytes of mediators related to myocardial remodeling, the expression pattern of activin A during clinical and experimental HF suggests an involvement of this cytokine in the pathogenesis of HF.
Yndestad et al. (Tue,) studied this question.