Activin A may play a role in the pathogenesis of heart failure by inducing gene expression related to myocardial remodeling.
Activin A inhibition merits testing in adult HF models; leaves open clinical relevance in patients.
Together with our demonstration of activin A-induced gene expression in neonatal cardiomyocytes of mediators related to myocardial remodeling, the expression pattern of activin A during clinical and experimental HF suggests an involvement of this cytokine in the pathogenesis of HF.
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Yndestad et al. (2004) studied this question.
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