Why the study?
Does early worsening renal function after initiation of ACE inhibitor therapy worsen prognosis in patients with cardiac dysfunction?
Does early worsening renal function after initiation of ACE inhibitor therapy worsen prognosis in patients with cardiac dysfunction?
Early worsening renal function after starting ACE inhibitors in patients with cardiac dysfunction is a benign event and does not negate the benefits of continued therapy.
Supports continuing ACE-I despite early worsening renal function; hypothesis-generating pending randomized confirmation.
These data support the notion that the mechanism underlying WRF is important in determining its prognostic significance. Specifically, early WRF in the setting of ACE-I initiation appears to represent a benign event that is not associated with a loss of benefit from continued ACE-I therapy.
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Testani et al. (2011) studied this question.
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