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This work aims to outline principles for organizing and standardizing metadata generated by the ENCODE project.

January 1, 2016Open Access

Principles of metadata organization at the ENCODE data coordination center

Key Points

This work aims to outline principles for organizing and standardizing metadata generated by the ENCODE project.
Outlining principles and philosophy for defining ENCODE metadata.
Creating a metadata standard applicable to diverse assays.
Presenting data validation methods for the ENCODE Portal.
Developed a metadata standard that can be applied across multiple genomic projects.
Established validation methods to ensure data quality for the ENCODE DCC.
Enhanced data accessibility through the ENCODE Portal.

Abstract

The Encyclopedia of DNA Elements (ENCODE) Data Coordinating Center (DCC) is responsible for organizing, describing and providing access to the diverse data generated by the ENCODE project. The description of these data, known as metadata, includes the biological sample used as input, the protocols and assays performed on these samples, the data files generated from the results and the computational methods used to analyze the data. Here, we outline the principles and philosophy used to define the ENCODE metadata in order to create a metadata standard that can be applied to diverse assays and multiple genomic projects. In addition, we present how the data are validated and used by the ENCODE DCC in creating the ENCODE Portal (https://www.encodeproject.org/). Database URL: www.encodeproject.org.

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