What question did this study set out to answer?

To develop 3D-printed bioactive ceramic scaffolds featuring micro/nano-hydroxyapatite surface layers formed via clean hydrothermal treatment and assess their ability to enhance vascularization and bone augmentation.

October 22, 2021SHILAP Revista de lepidopterologíaOpen Access

3D-printed bioactive ceramic scaffolds with biomimetic micro/nano-HAp surfaces mediated cell fate and promoted bone augmentation of the bone–implant interface in vivo

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Authors

XLXiao LiuHebei University of Economics and Business YMYali MiaoGuangdong University of Technology HLHaifeng LiangShanghai Medical Information Center

Discussion

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Implication

Preclinical study demonstrates that 3D-printed ceramic scaffolds with biomimetic hydroxyapatite surfaces promote bone augmentation and vascularization, indicating potential for bone regeneration.

Key Points

To develop 3D-printed bioactive ceramic scaffolds featuring micro/nano-hydroxyapatite surface layers formed via clean hydrothermal treatment and assess their ability to enhance vascularization and bone augmentation.
Fabricated interconnected porous composite ceramic scaffolds (β-TCP/CaSiO3) using 3D printing technology.
Synthesized an in situ uniform micro/nano-rod hybrid hydroxyapatite (HAp) surface layer via hydrothermal processing utilizing ultrapure water without mineral reagents or organic additives.
Evaluated cytocompatibility, osteogenic differentiation of mBMSCs, and gene expression of HUVECs in vitro, followed by in vivo assessment of capillary formation and bone matrix integration.
The biomimetic HAp surface layer reduced cytotoxicity, promoted cell adhesion, and upregulated both mBMSC osteogenic differentiation and HUVEC angiogenic gene expression in vitro.
In vivo implantation stimulated significant capillary formation, new bone matrix production, and accelerated bone augmentation at the bone–implant interface.

Cite This Study

Liu et al. (2021) studied this question.

synapsesocial.com/papers/69defbd01d9bba5129b0cf61 https://doi.org/10.1016/j.bioactmat.2021.10.016

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Implication

Preclinical study demonstrates that 3D-printed ceramic scaffolds with biomimetic hydroxyapatite surfaces promote bone augmentation and vascularization, indicating potential for bone regeneration.

3D-printed bioactive ceramic scaffolds with biomimetic micro/nano-HAp surfaces mediated cell fate and promoted bone augmentation of the bone–implant interface in vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

3D-printed bioactive ceramic scaffolds with biomimetic micro/nano-HAp surfaces mediated cell fate and promoted bone augmentation of the bone–implant interface in vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

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