Why the study?
Can MRI with ASL and MRE noninvasively evaluate physiological and structural changes in worsening diabetic nephropathy?
Can MRI with ASL and MRE noninvasively evaluate physiological and structural changes in worsening diabetic nephropathy?
MRI with ASL and MRE may serve as noninvasive tools to evaluate decreasing perfusion and tissue turgor in worsening diabetic nephropathy.
May support noninvasive MRI monitoring of perfusion in diabetic nephropathy; hypothesis-generating pilot data requiring prospective validation.
In this pilot study, MRI with ASL blood flow rates can noninvasively measure decreasing kidney cortical tissue perfusion and, with eGFR, a decreasing surrogate filtration fraction in worsening diabetic nephropathy that appears to correlate with increasing fibrosis. Differing from the liver, MRE shear stiffness surprisingly decreases with worsening CKD, likely related to decreased tissue turgor from lower blood flow rates.
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Brown et al. (2019) studied this question.