What question did this study set out to answer?

Review the concentration-dependent mechanisms of reactive oxygen species within the tumor microenvironment, focusing on their regulatory influence over tumor-infiltrating leukocytes.

August 16, 2019SHILAP Revista de lepidopterologíaOpen Access

Reactive Oxygen Species in the Tumor Microenvironment: An Overview

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Authors

FWFrank WeinbergUniversity of Illinois Chicago NRNithya RamnathTufts Medical Center DNDeepak NagrathUniversity of Michigan

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Implication

Review reveals dose-dependent reactive oxygen species signaling in the tumor microenvironment, highlighting therapeutic targets for remodeling leukocyte responses.

Key Points

Review the concentration-dependent mechanisms of reactive oxygen species within the tumor microenvironment, focusing on their regulatory influence over tumor-infiltrating leukocytes.
Literature synthesis examining the generation and biological functions of reactive oxygen species by malignant cells and stromal components.
Narrative evaluation of leukocyte responses to oxidative signaling and potential therapeutic interventions to alter the tumor microenvironment.
Reactive oxygen species exhibit opposing biological actions: low concentrations induce cellular proliferation, whereas high concentrations provoke tissue damage and cell death.
Both cancer cells and non-malignant stromal cells in the tumor microenvironment produce reactive oxygen species to modulate immune cell infiltration and leukocyte function.
Targeted pharmacological modulation of reactive oxygen species levels provides a pathway to reprogram the microenvironment and potentiate anti-tumor immune responses.

Cite This Study

Weinberg et al. (2019) studied this question.

synapsesocial.com/papers/69df14e54fb243fc8e5918a4 https://doi.org/10.3390/cancers11081191

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Implication

Review reveals dose-dependent reactive oxygen species signaling in the tumor microenvironment, highlighting therapeutic targets for remodeling leukocyte responses.

Reactive Oxygen Species in the Tumor Microenvironment: An Overview

Discussion

Member takes

Implication

Key Points

Cite This Study

Reactive Oxygen Species in the Tumor Microenvironment: An Overview

Discussion

Member takes

Implication

Key Points

Cite This Study

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