Temporal trends in pulmonary arterial hypertension: results from the COMPERA registry

Figures

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  FIGURE 1. STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) diagram showing eligibility for analysis. PAH: pulmonary arterial hypertension; mPAP: mean pulmonary arterial pressure; PAWP: pulmonary arterial wedge pressure. #: more than one reason for exclusion could apply.

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  FIGURE 2. Kaplan–Meier survival estimates overall and by pulmonary arterial hypertension (PAH) subtype. CHD: congenital heart disease; POPH: porto-pulmonary hypertension; I/H/D: idiopathic/heritable/drug-associated; CTD: connective tissue disease.

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  FIGURE 3. Temporal trends in the use of initial combination therapy and combination therapy 1 year after pulmonary arterial hypertension diagnosis in a) the entire cohort, and in the subgroups of patients aged b) <65 years and c) ≥65 years.

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  FIGURE 4. Annualised survival rates (95% CI) at 1 and 3 years after pulmonary arterial hypertension (PAH) diagnosis in a) the entire cohort, and in the subgroups of patients aged b) <65 years and c) ≥65 years. The black and red numbers indicate the numbers of patients available for the annualised 1- and 3-year survival rates, respectively.