May 25, 2004Proceedings of the National Academy of SciencesOpen Access

Bile acids are essential for porcine enteric calicivirus replication in association with down-regulation of signal transducer and activator of transcription 1

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Structured PICO

Population

LLC-PK cells infected with porcine enteric calicivirus (PEC), strain Cowden

Intervention

Bile acids and cAMP/protein kinase A pathway inhibitors (suramin, MDL12330A, or H89)

Outcome

PEC replication/growthsurrogate

Bile acids are essential for porcine enteric calicivirus replication in vitro, acting via the cAMP/PKA pathway and down-regulating innate immunity.

Discussion

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Implication

Bile acid-driven PEC replication via cAMP/PKA in porcine cells is hypothesis-generating; leaves open whether pathway inhibition offers antiviral targets in vivo.

Cite This Study

Chang et al. (2004) studied this question.

synapsesocial.com/papers/69df23884fb243fc8e59199b https://doi.org/10.1073/pnas.0401126101

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Implication

Bile acid-driven PEC replication via cAMP/PKA in porcine cells is hypothesis-generating; leaves open whether pathway inhibition offers antiviral targets in vivo.

Bile acids are essential for porcine enteric calicivirus replication in association with down-regulation of signal transducer and activator of transcription 1

Structured PICO

Discussion

Implication

Cite This Study

Bile acids are essential for porcine enteric calicivirus replication in association with down-regulation of signal transducer and activator of transcription 1

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider