What question did this study set out to answer?

Synthesize current evidence on the cellular and molecular mechanisms driving the vascular myogenic response to changes in transmural pressure, focusing primarily on arterioles.

April 1, 1999Physiological Reviews

Signaling Mechanisms Underlying the Vascular Myogenic Response

View Full Paper

Ask AI

Bookmark

Authors

MDMichael J. DavisUniversity of North Texas MHMichael A. HillVascular / Pulmonary Vascular

Discussion

Member takes

Implication

Narrative review reveals cellular signaling and mechanotransduction pathways driving the myogenic response in resistance arterioles, highlighting mechanisms that govern basal vascular tone.

Key Points

Synthesize current evidence on the cellular and molecular mechanisms driving the vascular myogenic response to changes in transmural pressure, focusing primarily on arterioles.
Reviewed biophysical and cellular investigations detailing mechanical behavior and electromechanical coupling in resistance vessels.
Analyzed literature on second messenger cascades, calcium mobilization, membrane-bound enzymes, integrins, and cytoskeletal dynamics.
Transmural pressure increases initiate electromechanical coupling and activate membrane-associated enzymes, driving intracellular calcium entry to induce vasoconstriction.
Extracellular matrix components, cell-surface integrins, and acute cytoskeletal reorganizations function as essential mechanotransducers sustaining basal vascular tone.

Cite This Study

Davis et al. (1999) studied this question.

synapsesocial.com/papers/69df238ab8d7e94566614a57 https://doi.org/10.1152/physrev.1999.79.2.387

View Full Paper

Ask AI

Bookmark

Implication

Narrative review reveals cellular signaling and mechanotransduction pathways driving the myogenic response in resistance arterioles, highlighting mechanisms that govern basal vascular tone.

Signaling Mechanisms Underlying the Vascular Myogenic Response

Discussion

Member takes

Implication

Key Points

Cite This Study

Signaling Mechanisms Underlying the Vascular Myogenic Response

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider