What question did this study set out to answer?

The study aims to compare the efficacy and safety of gentamicin with other antibiotics for acute appendicitis management.

April 15, 2026AntibioticsOpen Access

Open-Label Prospective Randomized Comparative Study of the Efficacy and Safety of Gentamicin in Comparison to Other Antibiotics in the Management of Acute Appendicitis in Surgically Treated Patients

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The study aims to compare the efficacy and safety of gentamicin with other antibiotics for acute appendicitis management.
Prospective randomized open-label study design
Compared gentamicin (once-daily) with ertapenem and cefuroxime plus metronidazole
Efficacy assessed through CRP dynamics and duration of treatment
Assessed nephrotoxicity using urine biomarkers
Statistical analysis utilized ANOVA and linear mixed model methods.
No significant differences in treatment durations and lengths of hospital stays among groups (p > 0.05)
Lowest CRP levels observed in the ertapenem group (p = 0.003)
Five complications recorded during hospitalization, two in the gentamicin group (p = 0.330)
No statistically significant differences in post-operative complications (p = 0.763)
Kidney injury biomarkers showed similar trends across all groups.

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This randomized study compares gentamicin to other antibiotics in managing acute appendicitis, suggesting its potential benefits.

Obolnar et al. (2026) studied this question.

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