Key result
Additional postoperative doses of ceftriaxone and metronidazole for 1 or 3 days did not significantly reduce surgical site infections compared to no further antibiotics (6.25% and 5.2% vs 8.2%).
Why the study?
Does extended postoperative antibiotic therapy reduce postoperative infective complications in patients with acute non-perforated appendicitis undergoing open appendectomy?
Population
317 patients aged 15 to 70 years with acute non-perforated appendicitis undergoing open appendectomy.
Comparison
Extended postoperative antibiotics: either 1 day… vs No further antibiotics after the initial…
Design
RCT, Randomized into one of three treatment protocols
Follow-up
10 days
Authors
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Supports limiting postoperative antibiotics to a single dose in non-perforated appendicitis; confirms no benefit from 1- or 3-day extensions in this RCT.
RCT (n=317)
randomized
Does extended postoperative antibiotic therapy reduce postoperative infective complications in patients with acute non-perforated appendicitis undergoing open appendectomy?
Absolute Event Rate: 6.25% vs 8.2%
A single postoperative dose of ceftriaxone and metronidazole appears sufficient for preventing surgical site infections in uncomplicated appendicitis, with no added benefit from extended antibiotic courses.
Rajabi‐Mashhadi et al. (2012) conducted an RCT in acute non-perforated appendicitis (n=317). Postoperative ceftriaxone and metronidazole vs. No further antibiotics was evaluated on Postoperative infective complication within the 10-day postoperative follow-up period. Additional postoperative doses of ceftriaxone and metronidazole for 1 or 3 days did not significantly reduce surgical site infections compared to no further antibiotics (6.25% and 5.2% vs 8.2%).
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