Why the study?
Does prophylactic metronidazole and ciprofloxacin prevent wound infection in adult Nigerian patients undergoing appendectomy for uncomplicated appendicitis?
Does prophylactic metronidazole and ciprofloxacin prevent wound infection in adult Nigerian patients undergoing appendectomy for uncomplicated appendicitis?
Routine prophylactic antibiotics (metronidazole and ciprofloxacin) do not appear to reduce wound infection rates in adult Nigerian patients undergoing appendectomy for uncomplicated appendicitis.
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Routine prophylactic antibiotics may not reduce wound infection after uncomplicated appendectomy; challenges routine use and supports larger confirmatory trials.
Background: Surgical site infection is of great concern to the surgeon hence preventive measures such as prophylactic antibiotics in widely used for clean contaminated and contaminated surgical procedures. This study seeks to evaluate any advantage gained by administering antibiotic in uncomplicated appendicitis. Method: A prospective randomized trial done on 70 patients admitted with appendicitis without features of peritonitis. Records were taken preoperatively and updated at the point of discharge and first clinic visit. Results: Wound infection occurred in 1 of 34 patients (2.9%) who had no antibiotic appendectomy against 2 of 36 who had metronidazole and ciprofloxacin. Mean age of patients was 22.8 years, and a mean hospital stay of 4.6 days. Conclusion: Routine antibiotic therapy is not necessary for adult Nigerian patients undergoing appendectomy for uncomplicated appendicitis.
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Kpolugbo et al. (2010) studied this question.
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