Key result
A single preoperative dose of antibiotics resulted in a similar rate of post-operative wound infection compared to a 5-day postoperative antibiotic course (10% vs 8%, p=0.727) in uncomplicated acute appendicitis.
Why the study?
Does a single dose preoperative antibiotic prevent post operative wound infection in uncomplicated acute appendicitis cases?
RCT (n=100)
Open-label
Alternating
No
Does a single dose preoperative antibiotic prevent post operative wound infection in uncomplicated acute appendicitis cases?
Absolute Event Rate: 10% vs 8%
p-value: p=0.727
Single dose preoperative antibiotics are effective in preventing post-operative wound infection in uncomplicated appendicitis, with a low overall incidence of 9%.
Supports limiting antibiotics to single preoperative dose in uncomplicated appendicitis; reinforces short-course prophylaxis as standard in appendectomy.
Background: The current practice in our hospital after appendectomy for uncomplicated acute appendicitis is continuation of antibiotics post operatively for 3- 5 days. No study regarding the duration of antibiotic use after appendectomy for acute uncomplicated appendicitis has been done in this institution before. Methods: This randomized control prospective study was conducted in IGMC SHIMLA from August 2017 to July 2018. Cases of uncomplicated acute appendicitis undergoing emergency open appendectomy were included in this study. Results: Out of 50 patients in group A, 5 (10%) developed wound infection. Out of 50 patients in group B, 4 (8%) patients developed wound infection. Over all incidence of wound infection was 9%. Conclusion: Frequency of post operative wound infection is generally very low in uncomplicated appendicitis and single dose pre operative antibiotics are effective in preventing post operative wound infection.
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Prashar et al. (2020) conducted an RCT in Uncomplicated acute appendicitis (n=100). Single dose preoperative antibiotics (Cefuroxime and Metronidazole) vs. Preoperative dose plus 5 days of postoperative antibiotics was evaluated on Post-operative wound infection (p=0.727). A single preoperative dose of antibiotics resulted in a similar rate of post-operative wound infection compared to a 5-day postoperative antibiotic course (10% vs 8%, p=0.727) in uncomplicated acute appendicitis.
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