Why the study?
Antibiotic prophylaxis reduces surgical site infection after appendectomy, but antibiotics are continued postoperatively with varying courses and combinations.
Does post-operative cefuroxime and metronidazole reduce post-operative wound infection in patients undergoing emergency open appendectomy for uncomplicated acute appendicitis?
Does post-operative cefuroxime and metronidazole reduce post-operative wound infection in patients undergoing emergency open appendectomy for uncomplicated acute appendicitis?
Prolonged use of post-operative antibiotics in uncomplicated acute appendicitis does not significantly reduce wound infection rates and is unnecessary.
Supports omitting post-operative antibiotics after uncomplicated appendectomy; reinforces evidence against routine use.
Background: The efficacy of antibiotic prophylaxis in patients undergoing appendectomy has been examined in several randomized and observational studies showing that appropriate use of antibiotics reduces the risk of SSI following appendectomy by 40-60%. These antibiotics are continued in postoperative period with different courses and combinations according to each case. Methods: This randomized control prospective study was conducted in IGMC SHIMLA from August 2017 to July 2018. Cases of uncomplicated acute appendicitis undergoing emergency open appendectomy were included in this study. Results: All the 9 patients who had wound infection developed superficial surgical site infection. None of the patients developed deep surgical site or intra abdominal infections in either of the two groups. Conclusion: Frequency of post operative wound infection is generally very low in uncomplicated appendicitis. The prolonged use of antibiotics post operatively is unnecessary, can increase antibiotic resistance, can produce side effects and increase cost of treatment.
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Prashar et al. (2020) studied this question.
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