Key result
A single preoperative dose of prophylactic antibiotics resulted in a 5.9% wound infection rate compared to 3.8% with quadruple doses (p=0.425), indicating a single dose is sufficient for acute non-complicated appendicitis.
Why the study?
Does a single dose of prophylactic antibiotics prevent postoperative complications as effectively as quadruple doses in patients with acute non-complicated appendicitis?
RCT (n=294)
Double-blind
Coin flip randomization
No
Does a single dose of prophylactic antibiotics prevent postoperative complications as effectively as quadruple doses in patients with acute non-complicated appendicitis?
Absolute Event Rate: 5.9% vs 3.8%
p-value: p=0.425
A single preoperative dose of prophylactic antibiotics is sufficient and as effective as a multiple-dose regimen for preventing wound infections in acute non-complicated appendicitis.
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Supports single-dose prophylaxis for acute appendicitis; extends evidence for antibiotic stewardship in uncomplicated surgical cases.
Khalifani et al. (2016) conducted an RCT in Acute non-complicated appendicitis (n=294). Cefazolin and Metronidazole vs. Quadruple doses (one preoperative dose plus three doses every 6 hours postoperatively) was evaluated on Wound infection (p=0.425). A single preoperative dose of prophylactic antibiotics resulted in a 5.9% wound infection rate compared to 3.8% with quadruple doses (p=0.425), indicating a single dose is sufficient for acute non-complicated appendicitis.
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