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This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds. Keywords: lead compound, isosterism, antagonist, pharmacodynamic, pharmacokinetic, hplc, prostaglandin-h synthase-2 (pghs-
Lima et al. (Sat,) studied this question.
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