What question did this study set out to answer?

The research aims to identify factors predicting treatment failure in children with HIV starting first-line therapy.

April 15, 2026Open Access

Predictors of treatment failure in children living with HIV starting first-line antiretroviral therapy in the ODYSSEY trial

The research aims to identify factors predicting treatment failure in children with HIV starting first-line therapy.
Analyzed data from the ODYSSEY trial
Focused on children beginning antiretroviral therapy
Evaluated age, BMI-for-age, and CD4% at treatment initiation
Young age is linked to higher treatment failure risk
Low BMI-for-age is associated with treatment challenges
Low CD4% at ART initiation points to increased failure instances

Young age, low BMI-for-age and low CD4% at ART initiation predicted higher risk of treatment failure and can guide targeted support.

Building similarity graph...

Analyzing shared references across papers

Wyncoll et al. (Thu,) studied this question.

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

James Wyncoll

Rujirek Kamolrattana

Moherndran Archary

Clinical Infectious Diseases

University College London

University of Padua

Goethe University Frankfurt

Building similarity graph...

Analyzing shared references across papers