Predictors of treatment failure in children living with HIV starting first-line antiretroviral therapy in the ODYSSEY trial

James Wyncoll; Rujirek Kamolrattana; Moherndran Archary; Hilda A. Mujuru; Adeodata R Kekitiinwa; Avy Violari; Sathaporn Na-Rajsima; Abbas Lugemwa; Ebrahim Variava; M. F. Cotton; Cissy M Kityo; C Königs; Ngundu Osee Behuhuma; Steve Welch; Yacine Saïdi; Laura Marques; Grace M Ahimbisibwe; Lily Houlden; Carlo Giaquinto; Pablo Rojo; D. M. F. Gibb; Thanyawee Puthanakit; Anna Turkova; Ellen White; D. J. Ford

doi:10.1093/cid/ciag232

Key Points

The research aims to identify factors predicting treatment failure in children with HIV starting first-line therapy.
Analyzed data from the ODYSSEY trial
Focused on children beginning antiretroviral therapy
Evaluated age, BMI-for-age, and CD4% at treatment initiation
Young age is linked to higher treatment failure risk
Low BMI-for-age is associated with treatment challenges
Low CD4% at ART initiation points to increased failure instances

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Observational analysis identifies young age, low BMI, and CD4% as predictors of treatment failure in HIV-positive children, suggesting targeted support strategies.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Wyncoll et al. (2026) studied this question.

synapsesocial.com/papers/69df2b2ce4eeef8a2a6b01b1 https://doi.org/10.1093/cid/ciag232

View Full Paper

Ask AI

Bookmark

Share

Predictors of treatment failure in children living with HIV starting first-line antiretroviral therapy in the ODYSSEY trial

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Predictors of treatment failure in children living with HIV starting first-line antiretroviral therapy in the ODYSSEY trial

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading