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April 15, 2026Therapeutic Advances in PsychopharmacologyOpen Access

Clozapine-related neutropenia and agranulocytosis in Korea: 2025 update for rethinking the role of monitoring system

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Authors

NKNuree KangGyeongsang National UniversityJJJi Seon JangKyungpook National University HospitalSJSung Woo Joo

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Implication

A retrospective cohort study examines clozapine-related neutropenia and agranulocytosis in Korea, suggesting updates to monitoring regulations.

Key Points

  • This study aims to update the incidence and clinical outcomes of clozapine-associated neutropenia and agranulocytosis in Korea.
  • Conducted a retrospective multicenter cohort study using electronic medical records from two Korean hospitals.
  • Included patients with schizophrenia who newly started clozapine between 2000 and 2023.
  • Assessed absolute neutrophil count to classify neutropenia and agranulocytosis.
  • Evaluated monitoring adherence based on ANC test intervals.
  • Neutropenia occurred in 9.7% of newly initiated clozapine patients.
  • Moderate neutropenia was found in 1.7%, mainly transient.
  • Ten agranulocytosis cases identified; four were clozapine-related and appeared abruptly.
  • Monitoring adherence was only 73.7% within the first 18 weeks, dropping below 50% after one year.

Cite This Study

Kang et al. (2026) studied this question.

synapsesocial.com/papers/69df2b2ce4eeef8a2a6b01bbhttps://doi.org/10.1177/20451253261440341
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Impact of Clozapine Delay on Clinical Outcomes in Schizophrenia2023 · 11 citations
  2. 2Immune-Mediated Adverse Drug Reactions2008 · 111 citations
  3. 3Meta‐analysis examining the epidemiology of clozapine‐associated neutropenia2018 · 237 citations
  4. 4The time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force2025 · 49 citations