Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 5, 2026Schizophrenia ResearchOpen Access

Baseline neutrophil count, benign ethnic neutropenia risk, and clozapine haematological monitoring: A multi-ethnic retrospective cohort study from the United Arab Emirates

View Full Paper
Ask AI
Bookmark
Share

Authors

SBSyed Ali BokhariDubai HospitalMEMuhanad ElnoorDubai HospitalMSMohamed SabriAbu Dhabi Health Services

Discussion

Loading...

Member takes

Implication

Retrospective cohort study examines neutrophil count and clozapine monitoring in a multi-ethnic population, suggesting improved safety measures.

Key Points

  • To assess baseline neutrophil count distribution, benign ethnic neutropenia risk, and post-initiation ANC outcomes in a clozapine cohort.
  • Conducted a retrospective cohort study at a psychiatric hospital in the UAE.
  • Included 179 adults with clozapine administration and at least one post-initiation ANC recorded.
  • Examined nationality-derived BEN-risk, monitoring intensity, and post-initiation ANC outcomes.
  • 88.3% of patients had no post-initiation ANC <2.0 × 10^9/L.
  • 1.1% reached conventional-threshold neutropenia; 1.7% severe neutropenia.
  • All five cases of clinically meaningful ANC <1.5 × 10^9/L had previous BEN-risk and valproate exposure.

Cite This Study

Bokhari et al. (2026) studied this question.

synapsesocial.com/papers/6a72e7c1226790f370656eefhttps://doi.org/10.1016/j.schres.2026.07.026
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of 96 cases of apparent clozapine-induced severe neutropenia2025 · 4 citations
  2. 2Benign Ethnic Neutropenia and Clozapine Use2016 · 53 citations
  3. 3Meta‐analysis examining the epidemiology of clozapine‐associated neutropenia2018 · 237 citations
  4. 4Need to bleed? Clozapine haematological monitoring approaches a time for change2019 · 22 citations
  5. 5Efficacy of clozapine versus second-generation antipsychotics in people with treatment-resistant schizophrenia: a systematic review and individual patient data meta-analysis2025 · 31 citations