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Cohort study compares β-lactam and non-β-lactam prophylaxis in elective colorectal surgery, indicating lower SSI risk with β-lactam.
In this cohort study of elective colorectal surgery procedures, β-lactam surgical prophylaxis was associated with significantly lower SSI risk compared with non-β-lactam alternatives. Differences in guideline-concordant dosing and timing between cohorts were not associated with SSI risk in adjusted analyses.
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Collins et al. (2026) studied this question.
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