What does this research mean for the field?

Sulbactam combined with ampicillin is a safe and effective alternative to cefoxitin for chemoprophylaxis in elective colorectal surgery, with no significant differences in wound sepsis or anastomotic leak rates. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1986Diseases of the Colon & Rectum

Sulbactam/ampicillin compared with cefoxitin for chemoprophylaxis in elective colorectal surgery

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Why the study?

Does sulbactam/ampicillin prevent wound sepsis in patients undergoing elective major colorectal surgery compared to cefoxitin?

Population

92 patients undergoing elective major colorectal surgery

Comparison

Sulbactam with ampicillin, four six-hour doses… vs Cefoxitin, four six-hour doses commencing at…

Design

RCT, randomized

Authors

MHM.N de la HuntUniversity of Cincinnati Medical Center SKS. J. KarranSouthampton General Hospital MCM. ChirHarvard University

Discussion

Member takes

Implication

Supports sulbactam/ampicillin as effective prophylaxis alternative to cefoxitin in colorectal surgery; extends antibiotic options.

Structured PICO

Does sulbactam/ampicillin prevent wound sepsis in patients undergoing elective major colorectal surgery compared to cefoxitin?

Population

92 patients undergoing elective major colorectal surgery

Intervention

Sulbactam with ampicillin (1 gm with 1 gm), four six-hour doses commencing at induction of anesthesia

Comparator

Cefoxitin (2 gm), four six-hour doses commencing at induction of anesthesia

Outcome

Wound sepsis (significant and minor), deep sepsis, and anastomotic leak rateshard clinical

Sulbactam combined with ampicillin is a safe and effective alternative to cefoxitin for prophylaxis in colorectal surgery.

Cite This Study

Hunt et al. (1986) studied this question.

synapsesocial.com/papers/6a1e656109554abc3868c63b https://doi.org/10.1007/bf02555011

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Sulbactam/ampicillin compared with cefoxitin for chemoprophylaxis in elective colorectal surgery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sulbactam/ampicillin compared with cefoxitin for chemoprophylaxis in elective colorectal surgery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider