Why the study?
Does single-dose cefotetan reduce infection rates compared to multiple-dose cefoxitin in patients undergoing colorectal surgery?
Population
403 evaluable patients undergoing colorectal surgery
Comparison
Cefotetan 2 gm intravenously at the beginning of… vs Cefoxitin 1 gm intravenously at the beginning of…
Design
RCT, randomized
Authors
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Supports single-dose cefotetan for colorectal prophylaxis; confirms simplified regimens reduce overall infections versus multi-dose cefoxitin.
Does single-dose cefotetan reduce infection rates compared to multiple-dose cefoxitin in patients undergoing colorectal surgery?
Single-dose cefotetan is as effective as multiple-dose cefoxitin for surgical prophylaxis in colorectal surgery, with a lower rate of nonsurgical site infections.
Periti et al. (1989) studied this question.
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