Key result
Postoperative cefepime shows no benefit over cefoxitin for infectious complications after colorectal cancer surgery.
Why the study?
The optimal antibiotic prophylaxis for preventing perioperative infection in patients aged 70 and older undergoing colorectal cancer surgery is unknown.
Does cefepime compared to cefoxitin improve perioperative outcomes and inflammatory response in elderly patients undergoing colorectal cancer surgery?
Population
107 elderly patients over 70 years undergoing colorectal cancer surgery in Shanghai, China
Comparison
Cefoxitin 2000 mg IV twice daily vs Cefepime 2000 mg IV twice daily for 3 days post-surgery
Design
Retrospective cohort study
Follow-up
During hospitalization
Authors
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Cefepime and cefoxitin show comparable perioperative safety in elderly colorectal surgery; this Level 3 finding leaves open whether the CD4+ difference affects outcomes.
Cohort (n=107)
No
Does cefepime compared to cefoxitin improve perioperative outcomes and inflammatory response in elderly patients undergoing colorectal cancer surgery?
Absolute Event Rate: 13.7% vs 12.5%
p-value: p=0.851
Both cefepime and cefoxitin are effective for perioperative prophylaxis in elderly colorectal cancer surgery patients, though cefepime may induce a more active early inflammatory response.
Liu et al. (2024) conducted a cohort in Colorectal cancer (n=107). Cefepime vs. Cefoxitin was evaluated on Overall perioperative infectious complications (p=0.851). In elderly patients undergoing colorectal cancer surgery, postoperative prophylaxis with cefepime did not significantly differ from cefoxitin in preventing overall perioperative infectious complications (13.7% vs 12.5%, P=0.851).
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