Key result
Perioperative cefazolin shows non-inferiority to cefuroxime for preventing surgical site infections.
Why the study?
The study was conducted to compare the risk of surgical site infections in intra-abdominal infections without sepsis following the implementation of a guideline setting cefazolin instead of cefuroxime as standard perioperative antibiotic prophylaxis.
Does cefazolin prevent surgical site infections as effectively as cefuroxime in patients undergoing emergency surgery for intra-abdominal infections without sepsis?
Population
587 patients receiving CXM or CFZ after emergency surgery for IAIs without sepsis
Comparison
Cefazolin vs cefuroxime for perioperative antibiotic prophylaxis
Design
Single-center quality improvement study with propensity score matching
Authors
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Cefazolin may be non-inferior for SSI prevention in this cohort; leaves open confirmation by randomized trials before practice change.
Observational (n=392)
No
Does cefazolin prevent surgical site infections as effectively as cefuroxime in patients undergoing emergency surgery for intra-abdominal infections without sepsis?
Absolute Event Rate: 7.1% vs 3.6%
p-value: p=0.117
Cefazolin appears non-inferior to cefuroxime for preventing surgical site infections in intra-abdominal infections without sepsis, though it may increase the risk of other postoperative infections.
Surat et al. (2022) conducted an observational in Intra-abdominal infections without sepsis (n=392). Cefazolin vs. Cefuroxime was evaluated on Surgical site infections (SSIs) (p=0.117). Perioperative prophylaxis with cefazolin resulted in a surgical site infection rate of 7.1% versus 3.6% for cefuroxime (p=0.117), remaining below the predefined non-inferiority margin.
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